Sounds fun...
I always used to listen to the reversed music when I had 4 tracks and tapes in the old days.... (gave me twice the music for the same price

)
I guess the only thing to avoid is the use of timed effects such as verbs and delays in this technic as the ones that are reversed could blur sounds and those which are not reversed (vst) would be, without the attack that is needed to use use them (reverbs especially) ? (EDIT: answer is in the first post

... ) .
if it is for attacks, you could use slow compression or an envelope follower or something like that (to blur out the attacks)...
(in FP mixers there is a level modulator that can do this with the "brush" setting that can remove attacks).